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NEW: High-potency Tru Niagen 500mg. Upgrade your cellular health.

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TRU NIAGEN 500mg supplement bottle with blue and silver design on a white background.
Hand holding a bottle of TRU NIAGEN 500mg supplement
A Tru Niagen bottle, showing the Supplement Facts panel and certification logos for “NSF Certified Sport”, "Kosher," and “Halal.” Each serving provides 439 mg of Niagen provided by 500mg of Nicotinamide riboside chloride.
A Tru Niagen supplement bottle displayed against a blurred background, highlighting key health benefits: cellular health, energy metabolism, tissue formation, nutrient metabolism, maintenance of good health, and cellular energy production.
Line chart showing that NAD+ levels in tissue decline by up to 65% between ages 30 and 70. The graph curves downward from age 30 to age 70, indicating a steady decrease. Text on the chart reads “NAD+ Decline ↓ 65%.” Source: Massudi et al., 2012; Janssens et al., 2022, based on analysis of human skin and muscle tissue.
Woman holding a glass of water with a testimonial quote from Sarah M about Tru Niagen that reads: "I've been using Tru Niagen for over a year now and feel great about supporting my cellular health daily. The quality and research behind this products gives me confidence in my choice!"
Tru Niagen® 500mg
Graphic featuring an image of Dr. Jim LaValle on a brown background, accompanied by a quote about the Tru Niagen supplement. The headline reads, “Backed by world-leading experts.” The quote says: "Tru Niagen stands out as the leading, gold-standard NAD+ [product]... It features patented (NR), which is the most efficient NAD+ precursor available." - Dr. Jim LaValle
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TRU NIAGEN 500mg supplement bottle with blue and silver design on a white background.

Our 500mg Tru Niagen is a source of vitamin B3 which increases levels of NAD+ in the blood, for the maintenance of good health. Clinically proven to increase blood NAD+ levels, to support cellular health.

Originally created for and exclusive to physicians and elite athletes, this professional-grade formula supports the production of cellular energy, as defined by adenosine triphosphate (ATP). 

Our key ingredient, Niagen®, is backed by world-leading researchers, currently featured in more than 65% of registered, ongoing, or completed clinical trials on nicotinamide riboside (NR).** 500mg of Tru Niagen provides 439 mg of NR.

Niagen was awarded Best Ingredient Supplier in 2019, highlighting our dedication to providing a well-researched and trusted source for healthy aging support.
Niagen was honored as the 2024 Healthy Aging Ingredient of the Year, underscoring our ingredient’s proven ability to promote long-term cellular resilience.
TESTED by SuppCo certified. Active ingredients independently verified by ISO 17025–accredited labs—anonymously purchased off the shelf, just like you would.

Tru Niagen® 500mg

Clinically researched, high-potency cellular energy support. Powered by Niagen®, this unique form of vitamin B3 is clinically proven to increase blood NAD+ levels, to support cellular health. Get the details.

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Our 500mg Tru Niagen is a source of vitamin B3 which increases levels of NAD+ in the blood, for the maintenance of good health. Clinically proven to increase blood NAD+ levels, to support cellular health.

Originally created for and exclusive to physicians and elite athletes, this professional-grade formula supports the production of cellular energy, as defined by adenosine triphosphate (ATP). 

Our key ingredient, Niagen®, is backed by world-leading researchers, currently featured in more than 65% of registered, ongoing, or completed clinical trials on nicotinamide riboside (NR).** 500mg of Tru Niagen provides 439 mg of NR.

Niagen was awarded Best Ingredient Supplier in 2019, highlighting our dedication to providing a well-researched and trusted source for healthy aging support.
Niagen was honored as the 2024 Healthy Aging Ingredient of the Year, underscoring our ingredient’s proven ability to promote long-term cellular resilience.
TESTED by SuppCo certified. Active ingredients independently verified by ISO 17025–accredited labs—anonymously purchased off the shelf, just like you would.

Backed by gold standard science and quality

Efficacy backed by peer-reviewed published research

Niagen® is supported by 45+ clinical studies demonstrating its efficacy. These human studies form the foundation of our scientific evidence. Over 65% of registered ongoing or completed nicotinamide riboside clinical trials use Niagen®.**

Partnership with 200+ institutions: We partner with top institutions like Mayo Clinic, National Institute on Aging, Harvard, and Cambridge.

Backed by independent research: 94% of Niagen® studies are independently peer-reviewed.
View studies and publications
A clinical trial published in Nature Communications 2016

Trammell et al., 2016.

A clinical trial published in Scientific Reports in 2019

Conze et al., 2019.

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Third-party verification for your health

We employ rigorous quality testing to support your health. Our science-backed supplements are routinely assessed by third-party testers for quality and potency.
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NSF Certified for Sport®

NSF’s Certified for Sport® is the only third-party certification recognized by United States Anti-Doping Agency (USADA), Major League Baseball (MLB), and the National Hockey League (NHL).

To earn this, supplements must meet strict quality standards, contain no unsafe contaminants, and be free of 270+ banned substances. Both Tru Niagen Stick Packs and Tru Niagen Pro are made in NSF-audited, GMP-certified facilities, with every batch verified for safety and transparency on NSF’s Certified for Sport® website.

Verified for Potency and Quality

Each batch of Tru Niagen® is verified by leading third-party labs to ensure purity and potency. Built on quality and transparency, every product meets the highest standards.

Visit our Quality page to access your bottle’s certificate of analysis.

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Backed by 25+ years of research & innovation

From the NAD+ authority trusted by physicians, athletes, researchers, and a Nobel Prize-winning biochemist.

45+

Human Clinical Studies on Niagen® NR

60+

Proprietary NR Patents

500+

Published Scientific Studies

300+

Global Research Collaborations

Reviews

Overall rating: 4.0 / 5 from 6 reviews.

AI Generated Review Summary

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Review highlights

Reviews

It works!

"Very effective product…I feel more energized!"

— BARNEY K. (5/5)

Great

"Happy"

— Daniel B. (4/5)

No changes

"After 4 months, I have not felt any changes whatsoever especially based on the monthly cost"

— Chris D. (2/5)

Didn’t do anything for me

"I read so many positive reviews and I really wanted to see improvement in my overall energy… but I really didn’t experience any noticeable difference."

— Susan B. (3/5)

Good

"I think it’s good so far."

— Yukiko N. (5/5)

Tru Niagen 500mg

"Very good"

— Qi M. (5/5)

Q&A

Frequently Asked Questions

1Prime Sale Terms & Conditions.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

**Based on registered ongoing or completed clinical trials under "nicotinamide riboside" on clinicaltrials.gov.

***Based on revenue per largest U.S. e-commerce marketplace (Jan. 2025 – Dec. 2025)

†In combination with a healthy lifestyle.

‡In reference to physiological (not mental) stress.

§For use beyond 12 weeks, consult a health care professional.